517 research outputs found
Atrial fibrillation management strategies in routine clinical practice: insights from the International RealiseAF Survey
Atrial fibrillation (AF) can be managed with rhythm- or rate-control strategies. There are few data from routine clinical practice on the frequency with which each strategy is used and their correlates in terms of patients' clinical characteristics, AF control, and symptom burden.RealiseAF was an international, cross-sectional, observational survey of 11,198 patients with AF. The aim of this analysis was to describe patient profiles and symptoms according to the AF management strategy used. A multivariate logistic regression identified factors associated with AF management strategy at the end of the visit.Among 10,497 eligible patients, 53.7% used a rate-control strategy, compared with 34.5% who used a rhythm-control strategy. In 11.8% of patients, no clear strategy was stated. The proportion of patients with AF-related symptoms (EHRA Class > = II) was 78.1% (n = 4396/5630) for those using a rate-control strategy vs. 67.8% for those using a rhythm-control strategy (p = II.In the RealiseAF routine clinical practice survey, rate control was more commonly used than rhythm control, and a change in strategy was uncommon, even in symptomatic patients. In almost 12% of patients, no clear strategy was stated. Physician awareness regarding optimal management strategies for AF may be improved
DWSB in heterotic flux compactifications
We address the construction of non-supersymmetric vacua in heterotic
compactifications with intrinsic torsion and background fluxes. In particular,
we implement the approach of domain-wall supersymmetry breaking (DWSB)
previously developed in the context of type II flux compactifications. This
approach is based on considering backgrounds where probe NS5-branes wrapping
internal three-cycles and showing up as four-dimensional domain-walls do not
develop a BPS bound, while all the other BPS bounds characterizing the N=1
supersymmetric compactifications are preserved at tree-level. Via a scalar
potential analysis we provide the conditions for these backgrounds to solve the
ten-dimensional equations of motion including order \alpha' corrections. We
also consider backgrounds where some of the NS5-domain-walls develop a BPS
bound, show their relation to no-scale SUSY-breaking vacua and construct
explicit examples via elliptic fibrations. Finally, we consider backgrounds
with a non-trivial gaugino condensate and discuss their relation to
supersymmetric and non-supersymmetric vacua in the present context.Comment: 56 pages, 1 figur
An enhanced static-list scheduling algorithm for temporal partitioning onto RPUs
This paper presents a novel algorithm for temporal partitioning of graphs representing a behavioral description. The algorithm is based on an extension of the traditional static-list scheduling that tailors it to resolve both scheduling and temporal partitioning. The nodes to be mapped into a partition are selected based on a statically computed cost model. The cost for each node integrates communication effects, the critical path length, and the possibility of the critical path to hide the delay of parallel nodes. In order to alleviate the runtime there is no dynamic update of the costs. A comparison of the algorithm to other schedulers and with close-to-optimum results obtained with a simulated annealing approach is shown. The presented algorithm has been implemented and the results show that it is robust, effective, and efficient, and when compared to other methods finds very good results in small amounts of CPU time
Improving healthcare delivery with new interactive visualization methods
Over the last years, the implementation and evolution of computer resources in hospital institutions has been improving both the financial and temporal efficiency of clinical processes, as well as the security in the transmission and maintenance of their data, also ensuring the reduction of clinical risk. Diagnosis, treatment and prevention of human illness are some of the most information-intensive of all intellectual tasks. Health providers often do not have or cannot find the information they need to respond quickly and appropriately to patientâs medical problems. Failure to review and follow up on patientâs test results in a timely manner, for example, represents a patientâs safety and malpractice concern. Therefore, it was sought to identify problems in a medical exams results management system and possible ways to improve this system in order to reduce both clinical risks and hospital costs. In this sense, a new medical exams visualization platform (AIDA-MCDT) was developed, specifically in the Hospital Center of Porto (CHP), with several new functionalities in order to make this process faster, intuitive and efficient, always guaranteeing the confidentiality and protection of patientsâ personal data and significantly improving the usability of the system, leading to a better health care delivery.FCT - Fundação para a CiĂȘncia e a Tecnologia (UID/CEC/00319/2019
Holomorphic variables in magnetized brane models with continuous Wilson lines
We analyze the action of the target-space modular group in toroidal type IIB
orientifold compactifications with magnetized D-branes and continuous Wilson
lines. The transformation of matter fields agree with that of twisted fields in
heterotic compactifications, constituting a check of type I/heterotic duality.
We identify the holomorphic N = 1 variables for these compactifications. Matter
fields and closed string moduli are both redefined by open string moduli. The
redefinition of matter fields can be read directly from the perturbative Yukawa
couplings, whereas closed string moduli redefinitions are obtained from D-brane
instanton superpotential couplings. The resulting expressions reproduce and
generalize, in the presence of internal magnetic fields, previous results in
the literature.Comment: 9 pages, no figures; v2: conventions for Wilson lines changed, major
simplifications in expressions, discussions extended, typos corrected, some
references adde
Dynamic SU(2) Structure from Seven-branes
We obtain a family of supersymmetric solutions of type IIB supergravity with
dynamic SU(2) structure, which describe the local geometry near a stack of four
D7-branes and one O7-plane wrapping a rigid four-cycle. The deformation to a
generalized complex geometry is interpreted as a consequence of nonperturbative
effects in the seven-brane gauge theory. We formulate the problem for
seven-branes wrapping the base of an appropriate del Pezzo cone, and in the
near-stack limit in which the four-cycle is flat, we obtain an exact solution
in closed form. Our solutions serve to characterize the local geometry of
nonperturbatively-stabilized flux compactifications.Comment: 49 pages, 2 figures; v2: minor corrections, references adde
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Tilted frames of reference have similar effects on perception of the gravitational vertical and the planning of vertical saccadic eye movements
We investigated the effects of a tilted reference frame (i.e., allocentric visual context) on perception of the gravitational vertical and saccadic eye movements along a planned egocentric vertical path. Participants (n=5) in a darkened room fixated a point in the center of a circle on an LCD display, and decided which of two sequentially presented dots was closer to the unmarked â6 oâclockâ position on that circle (i.e., straight down towards their feet). The slope of their perceptual psychometric functions showed that participants were able to locate which dot was nearer the vertical with a precision of 1-2°. For three of the participants, a square frame centered at fixation and tilted (in the roll direction) 5.6° from the vertical caused a strong perceptual bias, manifest as a shift in the psychometric function, in the direction of the traditional ârod and frameâ effect, without affecting precision. The other two participants showed negligible or no equivalent biases. The same subjects participated in the saccade version of the task, in which they were instructed to shift their gaze to the 6 oâclock position as soon as the central fixation point disappeared. The participants who showed perceptual biases showed biases of similar magnitude in their saccadic end points, with a strong correlation between perceptual and saccadic biases across all subjects. Tilting of the head 5.6° reduced both perceptual and saccadic biases in all but one observer, who developed a strong saccadic bias. Otherwise, the overall pattern and significant correlations between results remained the same. We conclude that our observers' saccades-to-the-vertical were dominated by perceptual input, which outweighed any gravitational or head-centered input
Moduli Stabilization and Cosmology of Type IIB on SU(2)-Structure Orientifolds
We consider type IIB flux compactifications on six-dimensional
SU(2)-structure manifolds with O5- and O7-planes. These six-dimensional spaces
allow not only for F_3 and H_3 fluxes but also for F_1 and F_5 fluxes. We
derive the four-dimensional N=1 scalar potential for such compactifications and
present one explicit example of a fully stabilized AdS vacuum with large volume
and small string coupling. We then discuss cosmological aspects of these
compactifications and derive several no-go theorems that forbid dS vacua and
slow-roll inflation under certain conditions. We also study concrete examples
of cosets and twisted tori and find that our no-go theorems forbid dS vacua and
slow-roll inflation in all but one of them. For the latter we find a dS
critical point with \epsilon numerically zero. However, the point has two
tachyons and eta-parameter \eta \approx -3.1.Comment: 35 pages + appendices, LaTeX2e; v2: numerical dS extremum added,
typos corrected, references adde
Holographic Vitrification
We establish the existence of stable and metastable stationary black hole
bound states at finite temperature and chemical potentials in global and planar
four-dimensional asymptotically anti-de Sitter space. We determine a number of
features of their holographic duals and argue they represent structural
glasses. We map out their thermodynamic landscape in the probe approximation,
and show their relaxation dynamics exhibits logarithmic aging, with aging rates
determined by the distribution of barriers.Comment: 100 pages, 25 figure
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